School of Pharmacy

The University of Mississippi

Dr. Paul D. Boudreau

Posted on: July 3rd, 2019 by wltarpy
Assistant Professor of Pharmacognosy and Assistant Research Professor in the Research Institute of Pharmaceutical Sciences
Faser Hall 405
662-915-3612
 

Education:

  • Postdoctoral Researcher, Harvard University, Department of Chemistry and Chemical
    Biology, Adviser: Prof. Emily P. Balskus
  • Ph.D., Scripps Institution of Oceanography, Department of Marine Biology, Adviser: Prof. William H. Gerwick
  • B.S., Massachusetts Institute of Technology, Department of Chemistry, Adviser: Prof. Rick L. Danheiser

Appointment(s):

  • Assistant Professor of Pharmacognosy
  • Assistant Research Professor in the Research Institute of Pharmaceutical Sciences

Career Highlights:

Paul Boudreau is an Assistant Professor of Pharmacognosy in the  School of Pharmacy. Dr. Boudreau worked as an undergraduate  researcher in Prof. Rick L. Danheiser’s lab at MIT, receiving his  B.S. in Chemistry in 2009. He conducted his graduate work with Prof.  William “Bill” H. Gerwick at the Scripps Institution of Oceanography,  defending his Ph.D. thesis “Orthogonality in Natural Products  Workflows” in 2015. Joining the laboratory of Prof. Emily P. Balskus  as a postdoctoral researcher he worked there until his appointment at  Ole Miss in 2019.

Research: 
Research in the Boudreau lab focuses on bacterial  natural products chemistry, using mass spectrometry and other tools  to probe the role of these compounds in shaping bacterial community  structure. This work aims to harness natural products as tools and  therapeutics to improve human health and treat disease. Specific  projects in the Boudreau lab include studying marine bacterial  symbioses, exploring the biomineralization of toxic metals by  bacteria, and probing the role of bacterial lipids in host immune  regulation. Students interested in joining the lab should reach out  to Prof. Boudreau directly through e-mail, undergraduates interested in an honors thesis project should view available projects in the Boudreau lab on the Undergraduate Research Database.

Publications:  

14 – Yindi J, Stornetta A, Villalta PW, Wilson MR, Boudreau PD, Zha L, Balbo S, Balskus EP.

“The reactivity of an unusual amidase may explain colibactin’s DNA cross-linking activity” J. Am. Chem. Soc. 2019, 141, 11489-11496.

13 – Wilson MR*, Jiang Y*, Villalta PW, Stornetta, A Boudreau PD, Carrá A, Brennan CA, Chun E, Ngo L, Samson LD, Engelward BP, Garrett WS, Balbo S, Balskus EP.

“The gut bacterial genotoxin colibactin alkylates mammalian cell DNA” Science. 2019, 363, eaar7785.

12 – Mascuch SJ, Boudreau PD, Carland TM, Pierce NT, Olson J, Hensler ME, Choi H, Campandale J, Hamdoun A, Nizet V, Gerwick WH, Gaasterland T, Gerwick L.

“Marine Natural Product Honaucin A Attenuates Inflammation by Activating the Nrf2-ARE Pathway” J. Nat. Prod. 2018, 81, 506-514.

11 – Naman CB, Rattan R, Nikoulina SE, Lee J, Miller BW, Moss NA, Armstrong L, Boudreau PD, Debonsi HM, Valeriote FA, Dorrestein PC, Gerwick WH.

“Integrating Molecular Networking and Biological Assays to Target the Isolation of a Cytotoxic Cyclic Octapeptide, Samoamide A, from an American Samoan Marine Cyanobacterium” J. Nat. Prod. 2017, 80, 625-633.

10 – Wang M, Carver JJ, Phelan VV, Sanchez LM, Garg N, Peng Y, Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, Porto C, Bouslimani A, Melnik AV, Meehan MJ, Liu WT, Crüsemann M, Boudreau PD, et al.

“Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking” Nat. Biotechnol.2016, 34, 828-837.

9 – Willumstad TP, Boudreau PD, Danheiser RL.

“Synthesis of Highly Substituted Quinolines via a Tandem Ynamide Benzeannulation/Iodicyclization Strategy” J. Org. Chem. 2015, 80, 11794-11805.

8 – Shao CL, Linington RG, Balunas MJ, Centeno A, Boudreau P, Zhang C, Engene N, Spadafora C, Mutka TS, Kyle DE, Gerwick L, Wang CY, Gerwick WH.

“Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine Cyanobacterium Okeania hirsutaJ. Org. Chem. 2015, 80, 7849-7855.

7Boudreau PD, Monroe EA, Mehrotra S, Desfor S, Korobeynikov A, Sherman DH, Murray TF, Gerwick L, Dorrestein PC, Gerwick WH.

“Expanding the Described Metabolome of the Marine Cyanobacterium Moorea producens JHB through Orthogonal Natural Products Workflows” PLoS ONE. 2015, 10, e0133297.

6 – Moree WJ, McConnell OJ, Nguyen DD, Sanchez LM, Yang YL, Zhao X, Liu WT, Boudreau PD, Srinivasan J, Arencio L, Ballesteros J, Gavilán RG, Torres-Mendoza D, Guzmán HM, Gerwick WH, Gutiérrez M, Dorrestein PC.

“Microbiota of Healthy Corals are Active Against Fungi in a Light Dependent Manner” ACS Chem. Biol. 2014, 9, 2300-2308.

5 – Mevers E, Haeckl, FPJ, Boudreau PD, Byrum T, Dorrestein PC, Valeriote FA, Gerwick WH. “Lipopeptides from the Tropical Marine Cyanobacrium Symploca sp.” J. Nat. Prod. 2014, 77, 969-975.

4 Liu WT, Lamsa A, Wong WR, Boudreau PD, Kersten R, Peng Y, Moree WJ, Duggan BM, Moore BS, Gerwick WH, Linington RG, Pogliano K, Dorrestein PC.

“MS/MS-based networking and peptidogenomics guided genome mining revealed the stenothricin gene cluster in Streptomyces roseosporus” J. Antibiotic. 2014, 67, 99-104.

3 – Gerwick L, Boudreau P, Choi H, Mascuch S, Villa FA, Balunas MJ, Malloy KL, Teasdale ME, Rowley DC, Gerwick WH.

“Interkingdom signaling by structurally related cyanobacterial and algal secondary metabolites” Phytochem. Rev. 2013, 12, 459-465.Top of Form

2 – Yang JY, Sanchez LM, Rath CM, Liu X, Boudreau PD, Bruns N, Glukhov E, Wodtke A, de Felicio R, Fenner A, Wong WR, Linington RG, Zhang L, Debonsi HM, Gerwick WH, Dorrestein PC.

“Molecular Networking as a Dereplication Strategy” J. Nat. Prod. 2013, 76, 1686-1689.

1Boudreau PD, Byrum T, Liu WT, Dorrestein PC, Gerwick WH.

“Viequeamide A, a Cytotoxic Member of the Kulolide Superfamily of Cyclic Depsipeptides from a Marine Button Cyanobacterium” J. Nat. Prod. 2012, 75, 1560-1570.