Medicinal Chemistry

The University of Mississippi

Medicinal Chemistry

Medicinal Chemistry is an interdisciplinary field, involving chemistry and important aspects of biological and pharmaceutical sciences. Medicinal Chemistry focuses on the discovery, design, and invention of biologically active compounds, the study of their metabolism, the interpretation of their modes of action at the molecular level, and the understanding of structure-activity relationships.

Our outstanding division offers research opportunities and graduate education on the discovery and development of new drugs as well as the exploitation of new biological targets for the treatment of cancer, malaria, CNS disorders, and infectious diseases. We blend conventional disciplines to conduct research in asymmetric organic synthesis, computational drug design, automated high-throughput synthesis and analysis, biological evaluation, and assay development.

Our mission is to continue producing highly trained graduates for careers in the Pharmaceutical Sciences and preparing them to be the next generation of leaders in academia and industry.

 

Ph.D. in Pharmaceutical Sciences

DESCRIPTION

The Ph.D. in pharmaceutical sciences can be completed with an emphasis in environmental toxicology, medicinal chemistry, pharmaceutics, pharmacology, pharmacognosy, or pharmacy administration.

MINIMUM TOTAL CREDIT HOURS: 54

COURSE REQUIREMENTS

Requirements for each emphasis area are given in the respective program description sections. Each emphasis area requires students to complete a minimum of 36 semester hours of course work and 18 hours of thesis.

Emphasis – Medicinal Chemistry

DESCRIPTION

A Ph.D. in pharmaceutical sciences with emphasis in medicinal chemistry prepares a graduate to perform basic and applied interdisciplinary research in drug discovery and development using the tools of computational chemistry, synthetic chemistry, and biological evaluation.  Current faculty research programs are focused in cancer, infectious disease, cardiometabolic disorders and neuroscience/drugs of abuse. 

Note: For more information, refer to the student handbook.

GOALS/MISSION STATEMENT

The mission of the Department of BioMolecular Sciences, Division of Medicinal Chemistry is to apply chemistry and the chemically related sciences to the teaching of professional pharmacy students and graduate students. The research mission of the department is the discovery, design, analysis, and further development of potential drugs and the discovery of potential drug design targets.

COURSE REQUIREMENTS

The course requirements for the Ph.D. with emphasis in medicinal chemistry consist of:

6 graduate core hours in medicinal chemistry (Advanced Medicinal Chemistry I (MEDC 501), Organic Chemistry of Drug Synthesis (MEDC 507);

2 common core hours (BMS 601: Graduate Student Survival Strategies);

12 hours of MEDC courses 600/700 level or BMS courses 700 level;

1 hour of Problems in Medicinal Chemistry (MEDC 541 or MEDC 542);

6 hours of Graduate-level electives (contingent upon Division of Medicinal Chemistry faculty approval);

1 hour Original Research Proposal (BMS 605).

Seminar Requirement – Students are required to register for BMS 643 (Z-grade) every semester, with the exception of those semesters in which the student presents a seminar and instead registers for BMS 641 (graded). No more than 8 seminar hours can be used toward the 54 minimum total credit hours

 A minimum of 18 hours of dissertation research must also be taken to meet degree requirements.

OTHER ACADEMIC REQUIREMENTS

Original Research Proposal – A student must prepare, submit, and successfully (orally) defend an original research proposal (ORP). Procedures for this requirement will be provided by the department. Students will register for BMS 605 (Original Research Proposal BioMolecular Sciences) in the semester they anticipate defending their ORP.

MALTO Presentation:  All graduate students in the Ph.D. program will be required to present their original research in the form of a podium presentation at one of the Annual MALTO Medicinal Chemistry Meetings-in-Miniature. 

Dissertation – A student must prepare and orally defend a dissertation based on original, independent research in partial fulfillment of their Ph.D. degree.

DEGREE REQUIREMENTS AND EXPECTATIONS

Medicinal Chemistry graduate students must meet a high level of academic achievement to maintain eligibility. Students are expected to maintain an overall GPA of at least 3.0 (B).

M.S. in Pharmaceutical Sciences

DESCRIPTION

The M.S. in pharmaceutical sciences can be completed with an emphasis in environmental toxicology, medicinal chemistry, pharmaceutics, pharmacology, pharmacognosy, or pharmacy administration.

MINIMUM TOTAL CREDIT HOURS: 30

COURSE REQUIREMENTS

Requirements for each emphasis area are given in the respective program description sections. Each emphasis area requires students to complete a minimum of 24 semester hours of course work and 6 hours of thesis.

Emphasis – Medicinal Chemistry

DESCRIPTION

A M.S. in pharmaceutical sciences with emphasis in medicinal chemistry is a multidisciplinary chemistry-centered science involved in applying both chemical and biological principles to a study of drugs capable of exerting specific effects on a biological system. In practice, the medicinal chemist is involved in designing, synthesizing and characterizing medicinal agents intended for the management and/or therapy of diseases.

Note: For more information, refer to the student handbook.

GOALS/MISSION STATEMENT

The mission of the Department of BioMolecular Sciences, Division of Medicinal Chemistry is to apply chemistry and the chemically related sciences to the teaching of professional pharmacy students and graduate students. The research mission of the department is the discovery, design, analysis, and further development of potential drugs and the discovery of potential drug design targets.

COURSE REQUIREMENTS

Requirements for the M.S. with an emphasis in medicinal chemistry consist of: Graduate Student Survival Strategies (BMS 601) (2 hours);

Advanced Medicinal Chemistry I (MEDC 501) (3 hours)

Organic Chemistry of Drug Synthesis (MEDC 507) (3 hours);

MEDC courses 600/700 level or BMS courses 700 level (6 hours);

Elective Courses (6 hours).

Seminar Requirement – Students are required to register for BMS 643 (Z-grade) every semester, with the exception of those semesters in which the student presents a seminar and instead registers for BMS 641 (graded). No more than 4 seminar hours can be used toward the 24 minimum total credit hours

A minimum of 6 hours of thesis research must also be taken to meet degree requirements.

OTHER ACADEMIC REQUIREMENTS

A thesis based upon experimental work in the general area of medicinal chemistry is required.

DEGREE REQUIREMENTS AND EXPECTATIONS

Medicinal Chemistry graduate students must meet a high level of academic achievement to maintain eligibility. Students are expected to maintain an overall GPA of at least 3.0 (B).

Med Chem Faculty

*Indicates Medicinal Chemistry Graduate Program Coordinator


Dr. David ColbyDavid Colby

Associate Professor of Medicinal Chemistry, Research Associate Professor in the Research Institute of Pharmaceutical Sciences and Director of Academic Affairs in BioMolecular Sciences

662-915-1766
dacolby@olemiss.edu

 

 


Dr. Robert Doerksen

Associate Dean of the Graduate School, Professor of Medicinal Chemistry and Research Professor in the Research Institute of Pharmaceutical Sciences

662-915-7052
rjd@olemiss.edu

 


Dr. Hoang Le*

Assistant Professor of Medicinal Chemistry and Research Assistant Professor in the Research Institute of Pharmaceutical Sciences

662-915-2555
hle@olemiss.edu

 

 


Dr. John RimoldiRimoldi

Professor of Medicinal Chemistry, Environmental Toxicology in BioMolecular Sciences and Research Professor in the Research Institute of Pharmaceutical Sciences and Director of Research and Graduate Affairs in BioMolecular Sciences

662-915-5119
jrimoldi@olemiss.edu

 

 


Dr. Sudeshna RoySudeshna Roy

Assistant Professor of Medicinal Chemistry and Pharmacognosy and Research Assistant Professor in the Research Institute of Pharmaceutical Sciences

662-915-2980
roy@olemiss.edu

 

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