The Center of Biomedical Research Excellence in Natural Products Neuroscience (COBRE-NPN) is a research and educational program at the University of Mississippi on the Oxford campus. It is funded by the National Institute of General Medical Sciences (NIGMS) at the National Institutes of Health (NIH) as one of its Centers of Biomedical Research Excellence (COBRE).

The University of Mississippi was awarded a five-year $11 million COBRE Phase I grant in September 2006. It was the first COBRE award made to the Oxford campus, which allowed investigators to conduct state-of-the-art research to identify components and properties of natural products that affect the nervous system. In the fall of 2012, the program was awarded a five-year $10 million COBRE Phase II grant. 

The Phase III award was received in August 2018 in the amount of approximately $5.3 million.