GlyCORE Publications

04/01/2022 - 03/31/2023 

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Phillips KE, Akbar S, Stevens DC. Concepts and conjectures concerning predatory performance of myxobacteria. Frontiers in Microbiology. 2022 Sep 29 doi.org/10.3389/fmicb.2022.1031346

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Rohini Dwivedi, Poonam Sharma, Friederike Eilts, Fuming Zhang, Robert J Linhardt, Ritesh Tandon, Vitor H Pomin, Anti-SARS-CoV-2 and anticoagulant properties of Pentacta pygmaea fucosylated chondroitin sulfate depend on high molecular weight structures, Glycobiology, 2022;, cwac063, doi.org/10.1093/glycob/cwac063

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Zhang W, Jin W, Pomin VH, Zhang F and Linhardt RJ (2022) Interactions of marine sulfated glycans with antithrombin and platelet factor 4. Front. Mol. Biosci. 9:954752. doi: 10.3389/fmolb.2022.954752. Published 19 September 2022.

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Fortenberry A, Mohammad SA, Werfel TA, Smith AE. Comparative Investigation of the Hydrolysis of Charge-Shifting Polymers Derived from an Azlactone-Based Polymer. Macromol Rapid Commun. 2022 Jul 12:e2200420. doi: 10.1002/marc.202200420. Epub ahead of print. PMID: 35820157.

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Dwivedi R, Sharma P, Farrag M, Kim SB, Fassero LA, Tandon R, Pomin VH. Inhibition of SARS-CoV-2 wild-type (Wuhan-Hu-1) and Delta (B.1.617.2) strains by marine Sulfated Glycans. Glycobiology. 2022 Jul 5:cwac042. doi: 10.1093/glycob/cwac042. Epub ahead of print. PMID: 35788318. (Published July 5, 2022)

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Khaje NA, Eletsky A, Biehn SE, Mobley CK, Rogals MJ, Kim Y, Mishra SK, Doerksen RJ, Lindert S, Prestegard JH, Sharp JS. Validated determination of NRG1 Ig-like domain structure by mass spectrometry coupled with computational modeling. Commun Biol. 2022 May 12;5(1):452. doi: 10.1038/s42003-022-03411-y. PMID: 35551273; PMCID: PMC9098640.

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Khatri HR, Han C, Alkhodier RA, Adam AT, Islam B, Colby DA. Generation of formaldehyde and formaldehyde-d2 for hydroxymethylations and hydroxydeuteromethylations of difluoroenolates and difluorobenzyl carbanions. Chem Commun (Camb). 2022 May 3;58(36):5490-5493. doi: 10.1039/d2cc01518h. PMID: 35416212; PMCID: PMC9205602.  (Published April 13, 2022)

Fig. 1. Structural modeling of GnT-V and N-glycan substrates

Vibhute AM, Tanaka HN, Mishra SK, Osuka RF, Nagae M, Yonekawa C, Korekane H, Doerksen RJ, Ando H, Kizuka Y. Structure-based design of UDP-GlcNAc analogs as candidate GnT-V inhibitors. Biochim Biophys Acta Gen Subj. 2022 Jun;1866(6):130118. doi: 10.1016/j.bbagen.2022.130118. Epub 2022 Mar 4. PMID: 35248671.

 

GlyCORE Publications

04/01/2021 - 03/31/2022 

Seon Beom Kim, Mary Zoepfl, Priyanka Samanta, Fuming Zhang, Ke Xia, Reena Thara, Robert J. Linhardt, Robert J. Doerksen, Michael A. McVoy, Vitor H. Pomin. Fractionation of sulfated galactan from the red alga Botryocladia occidentalis separates its anticoagulant and anti-SARS-CoV-2 properties. Journal of Biological Chemistry (2022) doi: https://doi.org/10.1016/j.jbc.2022.101856 (Published March 18, 2022)

 

Janke, Jonathan; Yu, Yanlei; Pomin, Vitor; Zhao, Jing; Wang, Chunyu; Linhardt, Robert; Garcia, Angel. Characterization of Heparin’s Conformational Ensemble by Molecular Dynamics Simulations and Nuclear Magnetic Resonance Spectroscopy. Journal of Chemical Theory and Computation (2022), doi: https://doi.org/10.1021/acs.jctc.1c00760 (Published Feb. 2, 2022)

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Mitra S, Talukdar K, Prasad P, Misra SK, Khan S, Sharp JS, Jurss JW, Chakraborty S. Rational Design of a Cu Chelator That Mitigates Cu-Induced ROS Production by Amyloid Beta. Chembiochem. 2022 Feb 16;23(4):e202100485. doi: 10.1002/cbic.202100485. Epub 2021 Dec 30. PMID: 34878720; PMCID: PMC9040527.

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Akbar S, Phillips KE, Misra SK, Sharp JS, Stevens DC. Differential response to prey quorum signals indicates predatory specialization of myxobacteria and ability to predate Pseudomonas aeruginosa. Environ Microbiol. 2022. Mar; 24(3):1263-1278. doi: 10.1111/1462-2920.15812. PubMed PMID: 34674390. (Epub Oct 21, 2021)

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Dwivedi R, Samanta P, Sharma P, Zhang F, Mishra SK, Kucheryavy P, Kim SB, Aderibigbe AO, Linhardt RJ, Tandon R, Doerksen RJ, Pomin VH, Structural and kinetic analyses of holothurian sulfated glycans suggest potential treatment for SARS-CoV-2 infection, Journal of Biological Chemistry (2021), doi: https://doi.org/10.1016/j.jbc.2021.101207 (Published Sept. 16, 2021)

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Pomin VH, Mahdi F, Jin W, Zhang F, Linhardt RJ, Paris JJ. Red Algal Sulfated Galactan Binds and Protects Neural Cells from HIV-1 gp120 and Tat. Pharmaceuticals. 2021; 14(8):714. https://doi.org/10.3390/ph14080714. (Published July 23, 2021)

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Akbar, S., Stevens, D.C. Functional genomics study of Pseudomonas putida to determine traits associated with avoidance of a myxobacterial predator. Sci Rep 11, 16445 (2021). doi: https://doi.org/10.1038/s41598-021-96046-8 (Published Aug. 12, 2021)

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Ahearne A, Albataineh H, Dowd SE, Stevens DC. Assessment of Evolutionary Relationships for Prioritization of Myxobacteria for Natural Product Discovery. Microorganisms. 2021; 9(7):1376. https://doi.org/10.3390/microorganisms9071376. (Published June 24, 2021)

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Sowaileh MF, Alshammari MD, Colby DA. Synthesis of Difluorinated Halohydrins by the Chemoselective Addition of Difluoroenolates to α-Haloketones. Organic Letters 2021 23 (13), 5098-5101. doi: 10.1021/acs.orglett.1c01636. (Published June 14, 2021)

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Cheng Z, Mobley C, Misra SK, Gadepalli RS, Hammond RI, Brown LS, Rimoldi JM, Sharp JS. Self-Organized Amphiphiles Are Poor Hydroxyl Radical Scavengers in Fast Photochemical Oxidation of Proteins Experiments. J Am Soc Mass Spectrom. 2021 May 5;32(5):1155-1161. doi: 10.1021/jasms.0c00457. Epub 2021 Apr 21. PMID: 33881849; PMCID: PMC8790760.

Adaikpoh BI, Dowd SE, Stevens DC. Draft Genome Sequence of Aneurinibacillus sp. Strain BA2021, Isolated as a Contaminant of a Laboratory-Cultivated Predatory Myxobacterium. Microbiol Resour Announc. 2021;10(17):e00243-21.  doi:10.1128/MRA.00243-21. (Published April 29, 2021)

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Zoepfl M, Dwivedi R, Taylor MC, Pomin VH, McVoy MA. Antiviral activities of four sulfated marine glycans against adenovirus and human cytomegalovirus. Antiviral Res. 2021 Apr 14:105077. doi: 10.1016/j.antiviral.2021.105077. Epub ahead of print. PMID: 33864843. (Published April 14, 2021)

05/15/2020 - 03/31/2021

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Tadi S, Misra SK, Sharp JS. Inline Liquid Chromatography-Fast Photochemical Oxidation of Proteins for Targeted Structural Analysis of Conformationally Heterogeneous Mixtures. Anal Chem. 2021 Feb 23;93(7):3510-3516. doi: 10.1021/acs.analchem.0c04872. Epub 2021 Feb 9. PMID: 33560821; PMCID: PMC7951798.

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Alshammari MD, Kucheryavy PV, Ashpole NM, Colby DA. Synthesis, biological evaluation, and NMR studies of 3-fluorinated derivatives of 3',4',5'-trihydroxyflavone and 3',4',5'-trimethoxyflavone. Bioorg Med Chem Lett. 2021 Jan 15;32:127720. doi: 10.1016/j.bmcl.2020.127720. Epub 2020 Nov 28. PMID: 33259925; PMCID: PMC7785688.

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Tandon R, Sharp JS, Zhang F, Pomin VH, Ashpole NM, Mitra D, McCandless MG, Jin W, Liu H, Sharma P, Linhardt RJ. Effective Inhibition of SARS-CoV-2 Entry by Heparin and Enoxaparin Derivatives. J Virol. 2021 Jan 13;95(3):e01987-20. doi: 10.1128/JVI.01987-20. PMID: 33173010; PMCID: PMC7925120.

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Shofolawe-Bakare OT , Stokes LD , Hossain M , Smith AE , Werfel TA . Immunostimulatory biomaterials to boost tumor immunogenicity. Biomater Sci. 2020 Oct 21;8(20):5516-5537. doi: 10.1039/d0bm01183e. Epub 2020 Sep 2. PMID: 33049007; PMCID: PMC7837217.

Photo of pathophysiology of heparin-induced thrombocytopenia (HIT).

Dwivedi R, Pomin VH. Marine Antithrombotics. Mar Drugs. 2020 Oct 13;18(10):514. doi: 10.3390/md18100514. PMID: 33066214; PMCID: PMC7602030.

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Liu H, Liang Q, Sharp JS. Peracylation Coupled with Tandem Mass Spectrometry for Structural Sequencing of Sulfated Glycosaminoglycan Mixtures without Depolymerization. J Am Soc Mass Spectrom. 2020 Oct 7;31(10):2061-2072. doi: 10.1021/jasms.0c00178. Epub 2020 Sep 18. PMID: 32902282; PMCID: PMC7664153.