GlyCORE Publications

04/01/2022 - 03/31/2023 

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Dwivedi R, Sharma P, Farrag M, Kim SB, Fassero LA, Tandon R, Pomin VH. Inhibition of SARS-CoV-2 wild-type (Wuhan-Hu-1) and Delta (B.1.617.2) strains by marine Sulfated Glycans. Glycobiology. 2022 Jul 5:cwac042. doi: 10.1093/glycob/cwac042. Epub ahead of print. PMID: 35788318. (Published July 5, 2022)

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Khatri HR, Han C, Alkhodier RA, Adam AT, Islam B, Colby DA. Generation of formaldehyde and formaldehyde-d2 for hydroxymethylations and hydroxydeuteromethylations of difluoroenolates and difluorobenzyl carbanions. Chem Commun (Camb). 2022 May 3;58(36):5490-5493. doi: 10.1039/d2cc01518h. PMID: 35416212; PMCID: PMC9205602.  (Published April 13, 2022)

GlyCORE Publications

04/01/2021 - 03/31/2022 

Seon Beom Kim, Mary Zoepfl, Priyanka Samanta, Fuming Zhang, Ke Xia, Reena Thara, Robert J. Linhardt, Robert J. Doerksen, Michael A. McVoy, Vitor H. Pomin. Fractionation of sulfated galactan from the red alga Botryocladia occidentalis separates its anticoagulant and anti-SARS-CoV-2 properties. Journal of Biological Chemistry (2022) doi: https://doi.org/10.1016/j.jbc.2022.101856 (Published March 18, 2022)

 

Fig. 1. Structural modeling of GnT-V and N-glycan substrates

Amol M. Vibhute, Hide-nori Tanaka, Sushil K. Mishra, Reina F. Osuka, Masamichi Nagae, Chizuko Yonekawa, Hiroaki Korekane, Robert J. Doerksen, Hiromune Ando, Yasuhiko Kizuka. Structure-based design of UDP-GlcNAc analogs as candidate GnT-V inhibitors. Biochimica et Biophysica Acta (BBA) - General Subjects (2022) doi: https://doi.org/10.1016/j.bbagen.2022.130118 (Published March 8, 2022)

 

Janke, Jonathan; Yu, Yanlei; Pomin, Vitor; Zhao, Jing; Wang, Chunyu; Linhardt, Robert; Garcia, Angel. Characterization of Heparin’s Conformational Ensemble by Molecular Dynamics Simulations and Nuclear Magnetic Resonance Spectroscopy. Journal of Chemical Theory and Computation (2022), doi: https://doi.org/10.1021/acs.jctc.1c00760 (Published Feb. 2, 2022)

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Akbar S, Phillips KE, Misra SK, Sharp JS, Stevens DC. Differential response to prey quorum signals indicates predatory specialization of myxobacteria and ability to predate Pseudomonas aeruginosa. Environ Microbiol. 2022. Mar; 24(3):1263-1278. doi: 10.1111/1462-2920.15812. PubMed PMID: 34674390. (Epub Oct 21, 2021)

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Dwivedi R, Samanta P, Sharma P, Zhang F, Mishra SK, Kucheryavy P, Kim SB, Aderibigbe AO, Linhardt RJ, Tandon R, Doerksen RJ, Pomin VH, Structural and kinetic analyses of holothurian sulfated glycans suggest potential treatment for SARS-CoV-2 infection, Journal of Biological Chemistry (2021), doi: https://doi.org/10.1016/j.jbc.2021.101207 (Published Sept. 16, 2021)

Stevens Photo from Research Article

Akbar, S., Stevens, D.C. Functional genomics study of Pseudomonas putida to determine traits associated with avoidance of a myxobacterial predator. Sci Rep 11, 16445 (2021). doi: https://doi.org/10.1038/s41598-021-96046-8 (Published Aug. 12, 2021)

Pomin photo from publication

Pomin VH, Mahdi F, Jin W, Zhang F, Linhardt RJ, Paris JJ. Red Algal Sulfated Galactan Binds and Protects Neural Cells from HIV-1 gp120 and Tat. Pharmaceuticals. 2021; 14(8):714. https://doi.org/10.3390/ph14080714. (Published July 23, 2021)

Research Photo for Ahearn/Albataineh

Ahearne A, Albataineh H, Dowd SE, Stevens DC. Assessment of Evolutionary Relationships for Prioritization of Myxobacteria for Natural Product Discovery. Microorganisms. 2021; 9(7):1376. https://doi.org/10.3390/microorganisms9071376. (Published June 24, 2021)

Research Photo for Publication

Sowaileh MF, Alshammari MD, Colby DA. Synthesis of Difluorinated Halohydrins by the Chemoselective Addition of Difluoroenolates to α-Haloketones. Organic Letters 2021 23 (13), 5098-5101. doi: 10.1021/acs.orglett.1c01636. (Published June 14, 2021)

Adaikpoh BI, Dowd SE, Stevens DC. Draft Genome Sequence of Aneurinibacillus sp. Strain BA2021, Isolated as a Contaminant of a Laboratory-Cultivated Predatory Myxobacterium. Microbiol Resour Announc. 2021;10(17):e00243-21.  doi:10.1128/MRA.00243-21. (Published April 29, 2021)

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Zoepfl M, Dwivedi R, Taylor MC, Pomin VH, McVoy MA. Antiviral activities of four sulfated marine glycans against adenovirus and human cytomegalovirus. Antiviral Res. 2021 Apr 14:105077. doi: 10.1016/j.antiviral.2021.105077. Epub ahead of print. PMID: 33864843. (Published April 14, 2021)

05/15/2020 - 03/31/2021

Scientific Image

Alshammari MD, Kucheryavy PV, Ashpole NM, Colby DA. Synthesis, biological evaluation, and NMR studies of 3-fluorinated derivatives of 3',4',5'-trihydroxyflavone and 3',4',5'-trimethoxyflavone. Bioorg Med Chem Lett. 2021 Jan 15;32:127720. doi: 10.1016/j.bmcl.2020.127720. Epub 2020 Nov 28. PMID: 33259925; PMCID: PMC7785688.

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Shofolawe-Bakare OT , Stokes LD , Hossain M , Smith AE , Werfel TA . Immunostimulatory biomaterials to boost tumor immunogenicity. Biomater Sci. 2020 Oct 21;8(20):5516-5537. doi: 10.1039/d0bm01183e. Epub 2020 Sep 2. PMID: 33049007; PMCID: PMC7837217.

Photo of pathophysiology of heparin-induced thrombocytopenia (HIT).

Dwivedi R, Pomin VH. Marine Antithrombotics. Mar Drugs. 2020 Oct 13;18(10):514. doi: 10.3390/md18100514. PMID: 33066214; PMCID: PMC7602030.

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Liu H, Liang Q, Sharp JS. Peracylation Coupled with Tandem Mass Spectrometry for Structural Sequencing of Sulfated Glycosaminoglycan Mixtures without Depolymerization. J Am Soc Mass Spectrom. 2020 Oct 7;31(10):2061-2072. doi: 10.1021/jasms.0c00178. Epub 2020 Sep 18. PMID: 32902282; PMCID: PMC7664153.