O-GlcNAc regulation of cellular physiology and pathophysiology

This conference will address the multitude of roles that the O-GlcNAc protein modification has in regulating nuclear and cytosolic proteins. It will bring together researchers from diverse fields to share their research, tools and experience in O-GlcNAc biology.

O-GlcNAc continues to be an underappreciated post-translational modification. However, the combination of advancements in determining protein-specific function and discovery that the modification is linked to many diseases have led to its recognition as an emerging target for understanding both normal and pathological processes in the cell.

The meeting will draw experts in O-GlcNAc biology from around the world to discuss how O-GlcNAc and O-GlcNAc cycling enzymes modulate protein function in basic biological processes as well as in disease states, including diabetes, cancer, cardiovascular disease and neurological diseases.

Graduate students and postdoctoral fellows, established in or wishing to learn about the field, are encouraged to attend and submit abstracts. The organizers will select oral presenters, and there will be a poster session.

Image: Y835 H-bonds to a helix proximal to UDP-GlcNAc in OGT-substrate complex. Structure from Schimpl et al, 2012. PDB: 4AY6.