InterestsCurrent topics of study in my lab: Investigating the symmetry between diabetic cardiomyopathy and heart failure by determining: 1) the changes in myocardial scaffolding components (i.e. total collagen and collagen type, and cross-linking of collagen fibers that comprise the extracellular part of tissue that provides structural support to the cells, 2) the role of autocrine and paracrine signaling messengers in regulating cell-cell as well as cell-tissue scaffolding matrix interaction (specifically, cardiac mast cells and ventricular fibroblasts) in myocardial remodeling, and 3) the mechanism of action for several anti-inflammation therapies (cyclo-oxygnease inhibitors, anti-diabetic agents and endo-cannabinoids) in preventing adverse ventricular remodeling in hypertensive, diabetic, and heart failure patients. |
