Department of Pharmaceutics and Drug Delivery
The University of Mississippi

Pharmaceutics and Drug Delivery Publications by Year

2020

  • Ajjarapu S, Rangappa S, Shankar VK, Shettar A, Kumar HNS, Kulkarni VI, Repka MA, Murthy SN. A Rapid Tool to Optimize Process Variables for Continuous Manufacturing of Metronidazole Ointment Using Melt Extrusion Technique. AAPS PharmSciTech. 2020;21(7):273
  • Alexander A, Agrawal M, Saraf S, Saraf S, Ajazuddin, Chougule MB. Formulation strategies of nano lipid carrier for effective brain targeting of anti-AD drugs. Curr Pharm Des. 2020
  • Alshetaili A, Alshahrani SM, Almutairy BK, Repka MA. Hot Melt Extrusion Processing Parameters Optimization. Processes. 2020;8(11):1516
  • Angamuthu M, Shivakumar HN, Murthy SN. Chapter 5 – Quality by Design (QbD) Principles in the Development of Transdermal Drug Delivery Products. In: Ghosh, TK. Dermal Drug Delivery: From Innovation to Production. 1st ed. Routledge; 2020
  • Bandari S, Nyavanandi D, Kallakunta VR, Janga KY, Sarabu S, Butreddy A, Repka MA. Continuous twin screw granulation – An advanced alternative granulation technology for use in the pharmaceutical industry. International journal of pharmaceutics. 2020;580:119215
  • Butreddy A, Bandari S, Repka MA. Quality-by-design in hot melt extrusion based amorphous solid dispersions: An industrial perspective on product development. Eur J Pharm Sci. 2020;158:105655
  • Butreddy A, Sarabu S, Bandari S, Dumpa N, Zhang F, Repka MA. Polymer-Assisted Aripiprazole–Adipic Acid Cocrystals Produced by Hot Melt Extrusion Techniques. Crystal Growth & Design. 2020;20(7):4335-45
  • Butreddy A, Sarabu S, Dumpa N, Bandari S, Repka MA. Extended release pellets prepared by hot melt extrusion technique for abuse deterrent potential: Category-1 in-vitro evaluation. Int J Pharm. 2020;587:119624
  • Dao HM, Husain I, Shankar VK, Khan SI, Murthy SN, Jo S. Insight into hydroxyl radical-mediated cleavage of caged methylene blue: the role of Fenton’s catalyst for antimalarial hybrid drug activation. Chem Commun (Camb). 2020;56(80):12017-12020
  • Dao HM, Whang CH, Shankar VK, Wang YH, Khan IA, Walker LA, Husain I, Khan SI, Murthy SN, Jo S. Methylene blue as a far-red light-mediated photocleavable multifunctional ligand. Chem Commun (Camb). 2020;56(11):1673-1676
  • Fatima T, Ajjarapu S, Shankar VK, Rangappa S, Shivakumar HN, Biswas SK, Hoque M, Murthy SN. Topical Pilocarpine Formulation for Diagnosis of Cystic Fibrosis. J Pharm Sci. 2020;109(5):1747-51
  • H P S, Matadh V A, Suresh S, Paul Guin J, Murthy S N, Kanni P, Varshney L, H N S. Effect of Gamma Sterilization on the Properties of Microneedle Array Transdermal Patch System. Drug Dev Ind Pharm. 2020:1-41

2019

  • Almutairi M, Almutairy B, Sarabu S, Almotairy A, Ashour E, Bandari S, Batra A, Tewari D, Durig T, Rekpa MA. Processability of AquaSolve™ LG polymer by hot-melt extrusion: Effects of pressurized CO2 on physicomechanical properties and API stability. Journal of Drug Delivery Science and Technology. 2019;52:165-76.
  • Alshehri S, Shakeel F, Elzayat E, Almeanazel O, Altamimi M, Shazly G, Kazi M, Almutairy B, Alsulays B, Alshetaili A, Alalaiwe A, Repka M. Rat palatability, pharmacodynamics effect and bioavailability of mefenamic acid formulations utilizing hot-melt extrusion technology. Drug Dev Ind Pharm. 2019;45(10):1610-6.
  • Bhatt P, Narvekar P, Lalani R, Chougule MB, Pathak Y, Sutariya V. An in vitro Assessment of Thermo-Reversible Gel Formulation Containing Sunitinib Nanoparticles for Neovascular Age-Related Macular Degeneration. AAPS PharmSciTech. 2019;20(7):281.
  • Chandra S, Radwan MM, Majumdar CG, Church JC, Freeman TP, ElSohly MA. New trends in cannabis potency in USA and Europe during the last decade (2008-2017). Eur Arch Psychiatry Clin Neurosci. 2019;269(1):5-15.
  • Dumpa N, Goel K, Guo Y, McFall H, Pillai AR, Shukla A, Repka MA, Murthy SN. Stability of Vaccines. AAPS PharmSciTech. 2019;20(2):42.
  • Fitts CA, Ji N, Li Y, Tan C. Exploiting Exosomes in Cancer Liquid Biopsies and Drug Delivery. Advanced healthcare materials. 2019;8(6):e1801268
  • Gandhi NS, Glasgow M, Chougule MB. Nanocarrier based pulmonary gene delivery for lung cancer: therapeutic and imaging approaches. Front Nanobiomed Res. 2018;11(Cancer Therapeutics and Imaging):89-136.
  • Ibrahim EA, Wang M, Radwan MM, Wanas AS, Majumdar CG, Avula B, Wang YH, Khan IA, Chandra S, Lata H, Hadad GM, Abdel Salam RA, Ibrahim AK, Ahmed SA, ElSohly MA. Analysis of Terpenes in Cannabis sativa L. Using GC/MS: Method Development, Validation, and Application. Planta Med. 2019;85(5):431-8.
  • Ibrahim M, Zhang J, Repka M, Chen R. Characterization of the Solid Physical State of API and Its Distribution in Pharmaceutical Hot Melt Extrudates Using Terahertz Raman Imaging. AAPS PharmSciTech. 2019;20(2):62.
  • Janga KY, Tatke A, Dudhipala N, Balguri SP, Ibrahim MM, Maria DN, Jablonski MM, Majumdar S. Gellan gum based sol-to-gel transforming system of natamycin transfersomes improves topical ocular delivery. J Pharmacol Exp Ther. 2019.
  • Kallakunta VR, Sarabu S, Bandari S, Batra A, V Bi, Durig T, Repka MA. Stable amorphous solid dispersions of fenofibrate using hot melt extrusion technology: Effect of formulation and process parameters for a low glass transition temperature drug. Journal of Drug Delivery Science and Technology. 2019;101395.
  • Kallakunta VR, Sarabu S, Bandari S, Tiwari R, Patil H, Repka MA. An update on the contribution of hot-melt extrusion technology to novel drug delivery in the twenty-first century: part I. Expert opinion on drug delivery. 2019;16(5):539-50.
  • Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, Dorjsuren D, Eastman RT, Huang R, Iannotti MJ, Karavadhi S, Klumpp-Thomas C, Roth JS, Sakamuru S, Sun W, Titus SA, Yasgar A, Zhang YQ, Zhao J, Andrade RB, Brown MK, Burns NZ, Cha JK, Mevers EE, Clardy J, Clement JA, Crooks PA, Cuny GD, Ganor J, Moreno J, Morrill LA, Picazo E, Susick RB, Garg NK, Goess C, Grossman RB, Hughes CC, Johnston JN, Joullie MM, Kinghorn AD, Kingston DGI, Krische MJ, Kwon O, Maimone TJ, Majumdar S, Maloney KN, Mohamed E, Murphy T, Nagorny P, Olson DE, Overman LE, Brown LE, Snyder JK, Porco JA Jr, Rivas F, Ross SA, Sarpong R, Sharma I, Shaw JT, Xu Z, Shen B, Shi W, Stephenson CRJ, Verano AL, Tan DS, Tang Y, Taylor RE, Thomson RJ, Vosburg DA, Wu J, Wuest WM, Zakarian A, Zhang Y, Ren T, Zuo Z, Inglese J, Michael S, Simeonov A, Zheng W, Shinn P, Jadhav A, Boxer MB, Hall MD, Xia M, Guha R, Rohde JM. Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. ACS Cent Sci. 2018;4(12):1727-41.
  • Lakhani P, Patil A, Wu K-W, Sweeney C, Tripathi S, Avula B, Taskar P, Khan S, Majumdar S. Optimization, stabilization, and characterization of amphotericin B loaded nanostructured lipid carriers for ocular drug delivery. International journal of pharmaceutics. 2019;572:118771.
  • Lalge R, Thipsay P, Shankar VK, Maurya A, Pimparade M, Bandari S, Zhang F, Murthy SN, Repka MA. Preparation and evaluation of cefuroxime axetil gastro-retentive floating drug delivery system via hot melt extrusion technology. International journal of pharmaceutics. 2019;566:520-31.
  • Mahaparale PR, Vinjamuri BP, Chavan MS, Chougule MB, Haware RV. Computational Predictability of Microsponge Properties Using Different Multivariate Models. AAPS PharmSciTech. 2019;20(5):172.
  • Maurya A, Rangappa S, Bae J, Dhawan T, Ajjarapu SS, Murthy SN. Evaluation of soluble fentanyl microneedles for loco-regional anti-nociceptive activity. International journal of pharmaceutics. 2019;564:485-91
  • Maurya A, Rangappa S, Bae J, Dhawan T, Ajjarapu SS, Murthy SN. Evaluation of soluble fentanyl microneedles for loco-regional anti-nociceptive activity. International journal of pharmaceutics. 2019;564:485-91.
  • McFall H, Sarabu S, Shankar V, Bandari S, Murthy SN, Kolter K, Langley N, Kim DW, Repka MA. Formulation of aripiprazole-loaded pH-modulated solid dispersions via hot-melt extrusion technology: In vitro and in vivo studies. International journal of pharmaceutics. 2019;554:302-11
  • Mendonsa N, Almutairy B, Kallakunta VR, Sarabu S, Thipsay P, Bandari S, Repka MA. Manufacturing strategies to develop amorphous solid dispersions: An overview. Journal of Drug Delivery Science and Technology. 2020;55:101459.
  • Mendonsa NS, Pradhan A, Sharma P, Prado RMB, Murthy SN, Kundu S, Repka MA. A quality by design approach to develop topical creams via hot-melt extrusion technology. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2019;136:104948.
  • Oblom H, Zhang J, Pimparade M, Speer I, Preis M, Repka M, Sandler N. 3D-Printed Isoniazid Tablets for the Treatment and Prevention of Tuberculosis-Personalized Dosing and Drug Release. AAPS PharmSciTech. 2019;20(2):52.
  • Panda A, Sharma PK, Narasimha Murthy S. Effect of Mild Hyperthermia on Transdermal Absorption of Nicotine from Patches. AAPS PharmSciTech. 2019;20(2):77
  • Sarabu S, Bandari S, Kallakunta VR, Tiwari R, Patil H, Repka MA. An update on the contribution of hot-melt extrusion technology to novel drug delivery in the twenty-first century: part II. Expert opinion on drug delivery. 2019;16(6):567-82
  • Taskar P, Adelli G, Patil A, Lakhani P, Ashour E, Gul W, ElSohly M, Majumdar S. Analog Derivatization of Cannabidiol for Improved Ocular Permeation. Journal of ocular pharmacology and therapeutics: the official journal of the Association for Ocular Pharmacology and Therapeutics. 2019;35(5):301-10.
  • Taskar PS, Patil A, Lakhani P, Ashour E, Gul W, ElSohly MA, Murphy B, Majumdar S. Δ(9)-Tetrahydrocannabinol Derivative-Loaded Nanoformulation Lowers Intraocular Pressure in Normotensive Rabbits. Transl Vis Sci Technol. 2019;8(5):15.
  • Tatke A, Dudhipala N, Janga KY, Soneta B, Avula B, Majumdar S. Melt-Cast Films Significantly Enhance Triamcinolone Acetonide Delivery to the Deeper Ocular Tissues. Pharmaceutics. 2019;11(4).
  • Ye X, Kallakunta V, Kim DW, Patil H, Tiwari RV, Upadhye SB, Vladyka RS, Repka MA. Effects of Processing on a Sustained Release Formulation Prepared by Twin-Screw Dry Granulation. Journal of pharmaceutical sciences. 2019.
  • Zhang J, Xu P, Vo AQ, Bandari S, Yang F, Durig T, Repka MA. Development and evaluation of pharmaceutical 3D printability for hot melt extruded cellulose-based filaments. Journal of Drug Delivery Science and Technology. 2019;52:292-302.

2018

  • Agrawal M, Saraf S, Saraf S, Antimisiaris SG, Chougule MB, Shoyele SA, Alexander A. Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs. Journal of Controlled Release. 2018;281:139-177.
  • Agrawal M, Saraf S, Saraf S, Antimisiaris SG, Hamano N, Li S-D, Chougule M, Shoyele SA, Gupta U, Ajazuddin, Alexander A. Recent advancements in the field of nanotechnology for the delivery of anti-Alzheimer drug in the brain region. Expert Opinion on Drug Delivery. 2018;15(6):589-617.
  • Bhagurkar, AM, Darji, M, Lakhani, P, Thipsay, P, Bandari, S, Repka, MA. Effects of formulation composition on the characteristics of mucoadhesive films prepared by hot-melt extrusion technology. The Journal of pharmacy and pharmacology. 2018.
  • Bookwala, M, Thipsay, P, Ross, S, Zhang, F, Bandari, S, Repka, MA. Preparation of a crystalline salt of indomethacin and tromethamine by hot melt extrusion technology. European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik eV. 2018;131:109-119.
  • Dao H, Lakhani P, Police A, Kallakunta V, Ajjarapu SS, Wu K-W, Ponkshe P, Repka MA, Narasimha Murthy S. Microbial Stability of Pharmaceutical and Cosmetic Products. AAPS PharmSciTech. 2018;19(1):60-78.
  • Darji, MA, Lalge, RM, Marathe, SP, Mulay, TD, Fatima, T, Alshammari, A, Lee, HK, Repka, MA, Narasimha Murthy, S. Excipient Stability in Oral Solid Dosage Forms: A Review. AAPS PharmSciTech. 2018;19(1):12-26.
  • Dumpa, NR, Sarabu, S, Bandari, S, Zhang, F, Repka, MA. Chronotherapeutic Drug Delivery of Ketoprofen and Ibuprofen for Improved Treatment of Early Morning Stiffness in Arthritis Using Hot-Melt Extrusion Technology. AAPS PharmSciTech. 2018;19(6):2700-2709.
  • Gandhi, NS, Godeshala, S, Koomoa-Lange, DT, Miryala, B, Rege, K, Chougule, MB. Bioreducible Poly(Amino Ethers) Based mTOR siRNA Delivery for Lung Cancer. Pharmaceutical research. 2018;35(10):188.
  • Gandhi, NS, Godeshala, S, Koomoa-Lange, DT, Miryala, B, Rege, K, Chougule, MB. Correction to: Bioreducible Poly(Amino Ethers) Based mTOR siRNA Delivery for Lung Cancer. Pharmaceutical research. 2018;35(11):202.
  • Haware, RV, Vinjamuri, BP, Gavireddi, M, Dave, VS, Gupta, D, Chougule, MC, Stagner, WC. Physical Properties and Solubility Studies of Nifedipine-PEG 1450/HPMCAS-HF Solid Dispersions. Pharmaceutical development and technology. 2018:1-23.
  • Janga KY, Tatke A, Balguri SP, P Lamichanne S, Ibrahim M, Maria D, Jablonski M, Majumdar S. Ion-sensitive in situ hydrogels of natamycin bilosomes for enhanced and prolonged ocular pharmacotherapy: in vitro permeability, cytotoxicity and in vivo evaluation. Artificial Cells. 2018:1-12.
  • Janga KY, Tatke A, Shukla S, Lamichhane SP, Avula B, Wang X, Jablonski MM, Khan IA, Majumdar S. Retina Compatible Interactions and Effective Modulation of Blood Ocular Barrier P-gp Activity by Third-Generation Inhibitors Improve the Ocular Penetration of Loperamide. Journal of Pharmaceutical Sciences. 2018.
  • Janga, KY, King, T, Ji, N, Sarabu, S, Shadambikar, G, Sawant, S, Xu, P, Repka, MA, Murthy, SN. Photostability Issues in Pharmaceutical Dosage Forms and Photostabilization. AAPS PharmSciTech. 2018;19(1):48-59.
  • Kallakunta, VR, Patil, H, Tiwari, R, Ye, X, Upadhye, S, Vladyka, RS, Sarabu, S, Kim, DW, Bandari, S, Repka, MA. Exploratory studies in heat-assisted continuous twin-screw dry granulation: A novel alternative technique to conventional dry granulation. International journal of pharmaceutics. 2018;555:380-393.
  • Lakhani P, Patil A, Majumdar S. Recent advances in topical nano drug-delivery systems for the anterior ocular segment. Therapeutic Delivery. 2018;9(2):137-153.
  • Lakhani, P, Patil, A, Majumdar, S. Challenges in the Polyene- and Azole-Based Pharmacotherapy of Ocular Fungal Infections. Journal of ocular pharmacology and therapeutics: the official journal of the Association for Ocular Pharmacology and Therapeutics. 2018.
  • Manda, P, Popescu, C, Juluri, A, Janga, K, Kakulamarri, PR, Narishetty, S, Narasimha Murthy, S, Repka, MA. Micronized Zaleplon Delivery via Orodispersible Film and Orodispersible Tablets. AAPS PharmSciTech. 2018;19(3):1358-1366.
  • Mendonsa NS, Murthy SN, Hashemnejad SM, Kundu S, Zhang F, Repka MA. Development of poloxamer gel formulations via hot-melt extrusion technology. International Journal of Pharmaceutics. 2018;537(1):122-131
  • Murthy SN, Repka MA. Excipient Stability: a Critical Aspect in Stability of Pharmaceuticals. AAPS PharmSciTech. 2018;19(1):11-11.
  • Patil A, Lakhani P, Taskar P, Wu K-W, Sweeney C, Avula B, Wang Y-H, Khan IA, Majumdar S. Formulation Development, Optimization, and In Vitro–In Vivo Characterization of Natamycin-Loaded PEGylated Nano-Lipid Carriers for Ocular Applications. Journal of Pharmaceutical Sciences. 2018.
  • Real D, Leonardi D, Williams R, A. Repka M, Salomon C. Solving the Delivery Problems of Triclabendazole Using Cyclodextrins. AAPS PharmSciTech. 2018;19.
  • Repka, MA, Bandari, S, Kallakunta, VR, Vo, AQ, McFall, H, Pimparade, MB, Bhagurkar, AM. Melt extrusion with poorly soluble drugs – An integrated review. International journal of pharmaceutics. 2018;535(1-2):68-85.
  • Sharma, PK, Avula, B, Panda, A, Wang, YH, Khan, IA, Murthy, SN. A sensitive bioanalytical method for quantitative determination of resiniferatoxin in rat plasma using ultra-high performance liquid chromatography coupled to tandem mass spectrometry and its application in pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2018;165:284-291
  • Sharma, PK, Panda, A, Pradhan, A, Zhang, J, Thakkar, R, Whang, CH, Repka, MA, Murthy, SN. Solid-State Stability Issues of Drugs in Transdermal Patch Formulations. AAPS PharmSciTech. 2018;19(1):27-35.
  • Tatke A, Janga KY, Avula B, Wang X, Jablonski MM, Khan IA, Majumdar S. Pglycoprotein Restricts Ocular Penetration of Loperamide across the Blood-Ocular Barriers: a Comparative Study in Mdr1a Knock-out and Wild Type Sprague Dawley Rats. AAPS PharmSciTech. 2018;19(4):1662-1671.
  • Tatke, A, Dudhipala, N, Janga, KY, Balguri, SP, Avula, B, Jablonski, MM, Majumdar, S. In Situ Gel of Triamcinolone Acetonide-Loaded Solid Lipid Nanoparticles for Improved Topical Ocular Delivery: Tear Kinetics and Ocular Disposition Studies. Nanomaterials (Basel, Switzerland). 2018;9(1).
  • Vo AQ, He H, Zhang J, Martin S, Chen R, Repka MA. Application of FT-NIR Analysis for In-line and Real-Time Monitoring of Pharmaceutical Hot Melt Extrusion: a Technical Note. AAPS PharmSciTech. 2018
  • Vo, AQ, Feng, X, Zhang, J, Zhang, F, Repka, MA. Dual mechanism of microenvironmental pH modulation and foam melt extrusion to enhance performance of HPMCAS based amorphous solid dispersion. International journal of pharmaceutics. 2018;550(1-2):216-228.
  • Wang, M, Li, Y, Srinivasan, P, Hu, Z, Wang, R, Saragih, A, Repka, MA, Murthy, SN. Interactions Between Biological Products and Product Packaging and Potential Approaches to Overcome Them. AAPS PharmSciTech. 2018;19(8):3681-3686.
  • Whang C-H, Lee HK, Kundu S, Murthy SN, Jo S. Pluronic-based dual-stimuli sensitive polymers capable of thermal gelation and pH-dependent degradation for in situ biomedical application. Journal of Applied Polymer Science. 2018;135(31):46552.
  • Whang, CH, Yoo, E, Hur, SK, Kim, KS, Kim, D, Jo, S. A highly GSH-sensitive SN-38 prodrug with an “OFF-to-ON” fluorescence switch as a bifunctional anticancer agent. Chemical communications (Cambridge, England). 2018;54(65):9031-9034.
  • Zhang J, Vo AQ, Feng X, Bandari S, Repka MA. Pharmaceutical Additive Manufacturing: a Novel Tool for Complex and Personalized Drug Delivery Systems. AAPS PharmSciTech. 2018.

2017

  • Adelli, Goutham R., Sai Prachetan Balguri, Prakash Bhagav, Vijayasankar Raman, and Soumyajit Majumdar. “Diclofenac sodium ion exchange resin complex loaded melt cast films for sustained release ocular delivery.” Drug Delivery 24, no. 1 (2017): 370-379.
  • Alshehri, Sultan M., Roshan V. Tiwari, Bader B. Alsulays, Eman A. Ashour, Abdullah S. Alshetaili, Bjad Almutairy, Jun-Bom Park et al. “Investigation of the combined effect of MgO and PEG on the release profile of mefenamic acid prepared via hot-melt extrusion techniques.” Pharmaceutical development and technology 22, no. 6 (2017): 740-753.
  • Alsulays, Bader B., Vijay Kulkarni, Sultan M. Alshehri, Bjad K. Almutairy, Eman A. Ashour, Joseph T. Morott, Abdullah S. Alshetaili, Jun-Bom Park, Roshan V. Tiwari, and Michael A. Repka. “Preparation and evaluation of enteric coated tablets of hot-melt extruded lansoprazole.” Drug development and industrial pharmacy 43, no. 5 (2017): 789-796.
  • Arunkumar, S., H. N. Shivakumar, and S. Narasimha Murthy. “Effect of terpenes on transdermal iontophoretic delivery of diclofenac potassium under constant voltage.” Pharmaceutical development and technology (2017): 1-9.
  • Balguri, Sai Prachetan, Goutham R. Adelli, Akshaya Tatke, Karthik Yadav Janga, Prakash Bhagav, and Soumyajit Majumdar. “Melt-Cast Noninvasive Ocular Inserts for Posterior Segment Drug Delivery.” Journal of pharmaceutical sciences 106, no. 12 (2017): 3515-3523.
  • Balguri, Sai Prachetan, Goutham R. Adelli, Karthik Yadav Janga, Prakash Bhagav, and Soumyajit Majumdar. “Ocular disposition of ciprofloxacin from topical, PEGylated nanostructured lipid carriers: Effect of molecular weight and density of poly (ethylene) glycol.” International journal of pharmaceutics 529, no. 1-2 (2017): 32-43.
  • Bhagurkar, Ajinkya M., Michael A. Repka, and S. Narasimha Murthy. “A Novel Approach for the Development of a Nanostructured Lipid Carrier Formulation by Hot-Melt Extrusion Technology.” Journal of pharmaceutical sciences 106, no. 4 (2017): 1085-1091.
  • Dao, Huy, Prit Lakhani, Anitha Police, Venkataraman Kallakunta, Sankar Srinivas Ajjarapu, Kai-Wei Wu, Pranav Ponkshe, Michael A. Repka, and S. Narasimha Murthy. “Microbial Stability of Pharmaceutical and Cosmetic Products.” AAPS PharmSciTech (2017): 1-19.
  • Darji, Mittal A., Rahul M. Lalge, Sushrut P. Marathe, Tarul D. Mulay, Tasnim Fatima, Alia Alshammari, Hyung Kyung Lee, Michael A. Repka, and S. Narasimha Murthy. “Excipient Stability in Oral Solid Dosage Forms: A Review.” AAPS PharmSciTech (2017): 1-15.
  • Dave, Vivek S., Hend I. Shahin, Susanne R. Youngren-Ortiz, Mahavir B. Chougule, and Rahul V. Haware. “Emerging technologies for the non-invasive characterization of physical-mechanical properties of tablets.” International journal of pharmaceutics (2017).
  • Evande, Ruby E., Rinku Dutta, Chalet Tan, Jean L. Grem, and Ram I. Mahato. “Pharmacogenomics of Neurodegenerative Diseases: Roles in Personalized Medicines.” In Neuroimmune Pharmacology, pp. 959-970. Springer International Publishing, 2017.
  • Gandhi, Nishant S., Micah Glasgow, and Mahavir B. Chougule. “NANOCARRIER BASED PULMONARY GENE DELIVERY FOR LUNG CANCER: THERAPEUTIC AND IMAGING APPROACHES.” Cancer Therapeutics And Imaging: Molecular And Cellular Engineering And Nanobiomedicine 11 (2017): 89.
  • Janga, Karthik Yadav, Tamara King, Nan Ji, Sandeep Sarabu, Gauri Shadambikar, Sagar Sawant, Pengchong Xu, Michael A. Repka, and S. Narasimha Murthy. “Photostability Issues in Pharmaceutical Dosage Forms and Photostabilization.” AAPS PharmSciTech (2017): 1-12.
  • Kushwaha, Avadhesh Singh, Michael A. Repka, and S. Narasimha Murthy. “A Novel Apremilast Nail Lacquer Formulation for the Treatment of Nail Psoriasis.” AAPS PharmSciTech (2017): 1-8.
  • Kushwaha, Avadhesh Singh, P. Sharma, H. N. Shivakumar, C. Rappleye, A. Zukiwski, S. Proniuk, and S. Narasimha Murthy. “Trans-ungual Delivery of AR-12, a novel antifungal drug.” AAPS PharmSciTech (2017): 1-4.
  • Kushwaha, Avadhesh Singh, P. Sharma, H. N. Shivakumar, C. Rappleye, A. Zukiwski, S. Proniuk, and S. Narasimha Murthy. “Trans-ungual Delivery of AR-12, a novel antifungal drug.” AAPS PharmSciTech (2017): 1-4.
  • Mendonsa, Nicole S., Priyanka Thipsay, Dong Wuk Kim, Scott T. Martin, and Michael A. Repka. “Bioadhesive Drug Delivery System for Enhancing the Permeability of a BCS Class III Drug via Hot-Melt Extrusion Technology.” AAPS PharmSciTech (2017): 1-9.
  • Park, Jun-Bom, Beom-Jin Lee, Chin-Yang Kang, Roshan V. Tiwari, and Michael A. Repka. “Process analytical quality control of tailored drug release formulation prepared via hot-melt extrusion technology.” Journal of Drug Delivery Science and Technology 38 (2017): 51-58
  • Patil, Akash, and Soumyajit Majumdar. “Echinocandins in antifungal pharmacotherapy.” Journal of Pharmacy and Pharmacology (2017).
  • Patil, Akash, and Soumyajit Majumdar. “Echinocandins in Ocular Therapeutics.” Journal of Ocular Pharmacology and Therapeutics 33, no. 5 (2017): 340-352.
  • Patil, Akash, Prit Lakhani, and Soumyajit Majumdar. “Current perspectives on natamycin in ocular fungal infections.” Journal of Drug Delivery Science and Technology 41 (2017): 206-212.
  • Patil, Akash, Supriya Bhide, Mustafa Bookwala, Bhavik Soneta, Vijaykumar Shankar, Ahmed Almotairy, Mashan Almutairi, and S. Narasimha Murthy. “Stability of Organoleptic Agents in Pharmaceuticals and Cosmetics.” AAPS PharmSciTech (2017): 1-12.
  • Pimparade, Manjeet B., Anh Vo, Abhijeet S. Maurya, Jungeun Bae, Joseph T. Morott, Xin Feng, Dong Wuk Kim et al. “Development and Evaluation of an Oral Fast Disintegrating Anti-allergic Film Using Hot-melt Extrusion Technology.” European Journal of Pharmaceutics and Biopharmaceutics (2017).
  • Punyamurthula, Nagendra S., Goutham R. Adelli, Waseem Gul, Michael A. Repka, Mahmoud A. ElSohly, and Soumyajit Majumdar. “Ocular Disposition of∆ 8-Tetrahydrocannabinol from Various Topical Ophthalmic Formulations.” AAPS PharmSciTech 18, no. 6 (2017): 1936-1945.
  • Sharma, Purnendu Kumar, Apoorva Panda, Adwait Pradhan, Jiaxiang Zhang, Ruchi Thakkar, Chang-Hee Whang, Michael A. Repka, and S. Narasimha Murthy. “Solid-State Stability Issues of Drugs in Transdermal Patch Formulations.” AAPS PharmSciTech (2017): 1-9.
  • Shegokar, Ranjita, Rajani Athawale, Nalini Kurup, Rongbing Yang, and Mahavir B. Chougule. “Lipid-Based Nanoparticles for Targeted Drug Delivery of Anticancer Drug.” Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes (2017): 287.
  • Taskar, Pranjal, Akshaya Tatke, and Soumyajit Majumdar. “Advances in the use of prodrugs for drug delivery to the eye.” Expert opinion on drug delivery 14, no. 1 (2017): 49-63.
  • Tekade, Rakesh K., Rahul Maheshwari, Muktika Tekade, and Mahavir B. Chougule. “Solid Lipid Nanoparticles for Targeting and Delivery of Drugs and Genes.” Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes (2017): 256.
  • Tekade, Rakesh K., Rahul Maheshwari, Namrata Soni, Muktika Tekade, and Mahavir B. Chougule. “Nanotechnology for the Development of Nanomedicine.” Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes (2017): 1.
  • Tiwari, Roshan V., Ashley N. Polk, Hemlata Patil, Xingyou Ye, Manjeet B. Pimparade, and Michael A. Repka. “Rat palatability study for taste assessment of caffeine citrate formulation prepared via hot-melt extrusion technology.” AAPS PharmSciTech 18, no. 2 (2017): 341-348.
  • Vo, Anh Q., Xin Feng, Manjeet Pimparade, Xinyou Ye, Dong Wuk Kim, Scott T. Martin, and Michael A. Repka. “Dual-mechanism gastroretentive drug delivery system loaded with an amorphous solid dispersion prepared by hot-melt extrusion.” European Journal of Pharmaceutical Sciences 102 (2017): 71-84.
  • Whang, Chang‐Hee, Kyeong Soo Kim, Jungeun Bae, Jun Chen, Ho‐Wook Jun, and Seongbong Jo. “Novel Biodegradable Polymer with Redox‐Triggered Backbone Cleavage Through Sequential 1, 6‐Elimination and 1, 5‐Cyclization Reactions.” Macromolecular rapid communications 38, no. 19 (2017).
  • Youngren-Ortiz, Susanne R., and Mahavir B. Chougule. “The Daniel K. Inouye College of Pharmacy Scripts: Targeted Nanocarrier Based Systems for the Treatment of Lung Cancer.” Hawai’i Journal of Medicine & Public Health 76.11 (2017): 318.
  • Youngren-Ortiz, Susanne R., David B. Hill, Peter R. Hoffmann, Kenneth R. Morris, Edward G. Barrett, M. Gregory Forest, and Mahavir B. Chougule. “Development of Optimized, Inhalable, Gemcitabine-Loaded Gelatin Nanocarriers for Lung Cancer.” Journal of Aerosol Medicine and Pulmonary Drug Delivery (2017).
  • Youngren-Ortiz, Susanne R., Nishant S. Gandhi, Laura España-Serrano, and Mahavir B. Chougule. “Aerosol Delivery of siRNA to the Lungs. Part 2: Nanocarrier-based Delivery Systems.” KONA Powder and Particle Journal 34 (2017): 44-69.
  • Zhang, Jiaxiang, Weiwei Yang, Anh Q. Vo, Xin Feng, Xingyou Ye, Dong Wuk Kim, and Michael A. Repka. “Hydroxypropyl methylcellulose-based controlled release dosage by melt extrusion and 3D printing: Structure and drug release correlation.” Carbohydrate polymers 177 (2017): 49-57.
  • Zhang, Jiaxiang, Xin Feng, Hemlata Patil, Roshan V. Tiwari, and Michael A. Repka. “Coupling 3D printing with hot-melt extrusion to produce controlled-release tablets.” International journal of pharmaceutics 519, no. 1 (2017): 186-197.

2016

  • Almutairy BK, Alshetaili AS, Ashour EA, Patil H, Tiwari RV, Alshehri SM, Repka MA. Development of a floating drug delivery system with superior buoyancy in gastric fluid using hot-melt extrusion coupled with pressurized CO2. Die Pharmazie. 2016;71(3):128-33
  • Alshehri SM, Tiwari RV, Alsulays BB, Ashour EA, Alshetaili AS, Almutairy B, Park JB, Morott J, Sandhu B, Majumdar S, Repka MA. Investigation of the combined effect of MgO and PEG on the release profile of mefenamic acid prepared via hot-melt extrusion techniques. Pharm Dev Technol. 2016 Jan 29:1-14
  • Alshetaili AS, Almutairy BK, Alshahrani SM, Ashour EA, Tiwari RV, Alshehri SM, Feng X, Alsulays BB, Majumdar S, Langley N, Kolter K, Gryczke A, Martin ST, Repka MA. Optimization of hot melt extrusion parameters for sphericity and hardness of polymeric facecut pellets. Drug Dev Ind Pharm. 2016 May 4:1-9
  • Alsulays B.B., Kulkarni V., Alshehri S.M., Almutairy B.K., Ashour E.A., Morott J.T., Alshetaili A.S., Park J.B., Tiwari R.V., Repka M.A. “Preparation and evaluation of enteric coated tablets of hot-melt extruded lansoprazole” Drug Dev Ind Pharm. 2016 Aug 21:1-8
  • Ashour EA, Majumdar S, Alsheteli A, Alshehri S, Alsulays B, Feng X, Gryczke A, Kolter K, Langley N, Repka MA. Hot melt extrusion as an approach to improve solubility, permeability and oral absorption of a psychoactive natural product, piperine. J Pharm Pharmacol. 2016 Aug; 68(8):989-98
  • Balguri S.P., Adelli G.R., Majumdar S. “Topical ophthalmic lipid nanoparticle formulations (SLN, NLC) of indomethacin for delivery to the posterior segment ocular tissues” Eur J Pharm Biopharm. 2016 Dec; 109:224-235
  • Bhagurkar A.M., Repka M.A., Murthy S.N. “A Novel Approach for the Development of a Nanostructured Lipid Carrier Formulation by Hot-Melt Extrusion Technology” J Pharm Sci. 2016 Dec 28
  • España-Serrano L and Chougule M.B. “Enhanced anticancer activity of PF-04691502, a dual PI3K/mTOR inhibitor, in combination with VEGF siRNA against non-small cell lung cancer” Molecular Therapy – Nucleic Acids (Nature publishing group), 2016 Nov 15
  • Kushwaha A, Shivakumar HN, Murthy SN. Iontophoresis for drug delivery into the nail apparatus: exploring hyponychium as the site of delivery. Drug Dev Ind Pharm. 2016 Apr 19:1-5 
  • Manda P, Kushwaha AS, Kundu S, Shivakumar HN, Jo SB, Murthy SN. Delivery Of ziconotide to cerebrospinal fluid via intranasal pathway for the treatment of chronic pain. J Control Release.2016Feb28;224:69-76
  • Modepalli N, Shivakumar HN, Kanni KL, Murthy SN. Transdermal iron replenishment therapy. Ther Deliv. 2015;6(6):661-8
  • Modepalli N, Shivakumar HN, McCrudden MT, Donnelly RF, Banga A, Murthy SN. Transdermal Delivery of Iron Using Soluble Microneedles: Dermal Kinetics and Safety.  JPharmSci.2016  Mar; 105(3): 119200
  • Mohammed N.N., Pandey P, Khan N.S., Elokely K.M., Liu H, Doerksen R.J., Repka M.A. “Clotrimazole-cyclodextrin based approach for the management and treatment of Candidiasis – A formulation and chemistry-based evaluation” Pharm Dev Technol. 2016 Aug;21(5):619-29
  • Patil H, Tiwari RV, Repka MA. Recent advancements in mucoadhesive floating drug delivery systems: A mini-review. J Drug Deliv Sci Tec. 2016 Feb;31:65-71
  • Punyamurthula N.S., Adelli G.R., Gul W, Repka M.A., ElSohly M.A., Majumdar S. “Ocular Disposition of ∆(8)-Tetrahydrocannabinol from Various Topical Ophthalmic Formulations” AAPS PharmSciTech. 2016 Nov 30
  • Taskar P., Tatke A., Majumdar S. “Advances in the use of prodrugs for drug delivery to the eye” Expert Opin Drug Deliv. 2017 Jan;14(1):49-63
  • Tiwari RV, Patil H, Repka MA. Contribution of hot-melt extrusion technology to advance drug delivery in the 21st century. Expert Opin Drug Deliv. 2016;13(3):451- 64
  • Zhang F, Repka MA. Pharmaceutical Thermal Processing. AAPS PharmSciTech. 2016 Feb;17(1):1-2
  • Zhang, J, Feng, X, Patil, H, Tiwari, R.V., Repka M.A. “Coupling 3D printing with hotmelt extrusion to produce controlled-release tablets” Int J Pharm. 2016 Dec 23;519(1- 2):186-197

2015

  • Ashour E, Kulkarni V, Almutairy B, Park JB, Shah SP, Majumdar S, Lian Z, Pinto E, Bi V, Durig T, Martin ST, Repka MA. Influence of pressurized carbon dioxide on ketoprofen-incorporated hot-melt extruded low molecular weight hydroxypropylcellulose. Drug Dev Ind Pharm. 2015 May 22:1-8
  • Adelli GR, Balguri SP, Majumdar S. Effect of Cyclodextrins on Morphology and Barrier Characteristics of Isolated Rabbit Corneas. AAPS PharmSciTech. 2015 Mar 14
  • Adelli GR, Hingorani T, Punyamurthula N, Balguri SP, Majumdar S. Evaluation of topical hesperetin matrix film for back-of-the-eye delivery. Eur J Pharm Biopharm. 2015 May;  92:74-82
  • Alshahrani SM, Lu W, Park JB, Morott JT, Alsulays BB, Majumdar S, Langley N, Kolter K, Gryczke A, Repka MA. Stability-enhanced Hot-melt Extruded Amorphous Solid Dispersions via Combinations of Soluplus® and HPMCAS-HF. AAPS PharmSciTech. 2015 Jan 8.
  • Alshahrani SM, Morott JT, Alshetaili AS, Tiwari RV, Majumdar S, Repka MA. Influence of degassing on hot-melt extrusion process. Eur J Pharm Sci. 2015 Dec 1; 80:43-52. PMC4667714
  • Alshehri SM, Park JB, Alsulays BB, Tiwari RV, Almutairy B, Alshetaili AS, Morott J, Shah S, Kulkarni V, Majumdar S, Martin ST, Mishra S, Wang L, Repka MA. Mefenamic acid taste-masked oral disintegrating tablets with enhanced solubility via molecular interaction produced by hot melt extrusion technology. J Drug Deliv Sci Technol. 2015 Jun 1;27:18-27
  • Alshetaili AS, Almutairy BK, Tiwari RV, Morott JT, Alshehri SM, Feng X, Alsulays BB, Park JB, Zhang F, Repka MA. Preparation and Evaluation of Hot-Melt Extruded PatientCentric Ketoprofen Mini-tablets. Curr Drug Deliv. 2015 Oct 12
  • Alsulays BB, Park JB, Alshehri SM, Morott JT, Alshahrani SM, Tiwari RV Alshetaili AS, Majumdar S, Langley N, Kolter K, Gryczke A, Repka MA. Influence of Molecular Weight of Carriers and Processing Parameters on the Extrudability, Drug Release, and Stability of Fenofibrate Formulations Processed by Hot-Melt Extrusion. J Drug Deliv Sci Technol. 2015 Oct 1; 29: 189-198
  • Bae J, Maurya A, Shariat-Madar Z, Murthy SN, Jo S. Novel Redox-Responsive Amphiphilic Copolymer Micelles for Drug Delivery: Synthesis and Characterization. AAPS J. 2015 Jun 27.
  • Bae J, McNamara LE, Nael MA, Mahdi F, Doerksen RJ, Bidwell GL 3rd, Hammer NI, Jo S. Nitroreductase-triggered activation of a novel caged fluorescent probe obtained from methylene blue. Chem Commun (Camb). 2015 Aug 18; 51(64)
  • Bhagurkar AM, Angamuthu M, Patil H, Tiwari RV, Maurya A, Hashemnejad SM, Kundu S, Murthy SN, Repka MA. Development of an Ointment Formulation Using Hot-Melt Extrusion Technology. AAPS PharmSciTech. 2015 Dec 1
  • Feng X, Vo A, Patil H, Tiwari RV, Alshetaili AS, Pimparade MB, Repka MA. The effects of polymer carrier, hot melt extrusion process and downstream processing parameters on the moisture sorption properties of amorphous solid dispersions. J Pharm Pharmacol. 2015 Nov 21
  • Feng X, Ye X, Park JB, Lu W, Morott J, Beissner B, Lian ZJ, Pinto E, Bi V, Porter S, Durig T, Majumdar S, Repka MA. Evaluation of the recrystallization kinetics of hot-melt extruded polymeric solid dispersions using an improved Avrami equation. Drug Dev Ind Pharm. 2015; 41(9):1479-87
  • Juluri A, Popescu C, Zhou L, Murthy RN, Gowda VK, P CK, Pimparade MB, Repka MA, Murthy SN. Taste Masking of Griseofulvin and Caffeine Anhydrous Using Kleptose Linecaps DE17 by Hot Melt Extrusion
  • Lu J, Cuellar K, Hammer NI, Jo S, Gryczke A, Kolter K, Langley N, Repka MA. Solid-state characterization of Felodipine-Soluplus amorphous solid dispersions. Drug Dev Ind Pharm. 2015 Nov 4:1-12
  • NN Mohammed; P Pandey; KM Elokely; HL Liu; RJ Doerksen; MA Repka “Clotrimazole-cyclodextrin based approach for the management and treatment of Candidiasis. A formulation and chemistry based evaluation,” accepted to Pharmaceutical Development and Technology (2015)
  • Palem CR, Dudhipala NR, Battu SK, Repka MA, Rao Yamsani M. Development, optimization and in vivo characterization of domperidone-controlled release hot-meltextruded films for buccal delivery. Drug Dev Ind Pharm. 2015 Nov 4:1-12
  • Patil H, Tiwari RV, Repka MA. Hot-Melt Extrusion: from Theory to Application in Pharmaceutical Formulation. AAPS PharmSciTech. 2015 Jul 10
  • Patil H, Tiwari RV, Upadhye SB, Vladyka RS, Repka MA. Formulation and development of pH-independent/dependent sustained release matrix tablets of ondansetron HCl by a continuous twin-screw melt granulation process. Int J Pharm.2015 Apr 8
  • Patil HG, Tiwari RV, Repka MA, Singh KK. Formulation and development of orodispersible sustained release tablet of domperidone. Drug Dev Ind Pharm. 2015 Oct 16: 1-10
  • Patwardhan K, Asgarzadeh F, Dassinger T, Albers J, Repka MA. A quality by design approach to understand formulation and process variability in pharmaceutical melt extrusion processes. J Pharm Pharmacol. 2015 Jan 23.
  • Pimparade MB, Morott JT, Park JB, Kulkarni VI, Majumdar S, Murthy SN, Lian Z, Pinto E, Bi V, Durig T, Murthy R, H N S, Vanaja K, Kumar P C, Repka MA. Development of taste masked caffeine citrate formulations utilizing hot melt extrusion technology and in vitro-in vivo evaluations. Int J Pharm. 2015 Jun 20;487(1-2):167-76
  • Pradhan M, Singh D, Murthy SN, Singh MR. Design, characterization and skin permeating potential of Fluocinolone acetonide loaded nanostructured lipid carriers for topical treatment of psoriasis. Steroids. 2015 Jun 3;101:56-63
  • Punyamurthula NS, Hingorani T, Adelli G, Gul W, ElSohly MA, Repka MA, Majumdar S. Controlled release tablet formulation containing natural Δ(9)-tetrahydrocannabinol. Drug Dev Ind Pharm. 2015 Dec 7:1-7
  • Tiwari RV, Polk AN, Patil H, Ye X, Pimparade MB, Repka MA. Rat Palatability Study for Taste Assessment of Caffeine Citrate Formulation Prepared via Hot-Melt Extrusion Technology. AAPS PharmSciTech. 2015 Nov 16
  • Vo AQ, Feng X, Morott JT, Pimparade MB, Tiwari RV, Zhang F, Repka MA. A Novel Floating Controlled Release Drug Delivery System Prepared by Hot-Melt Extrusion. Eur J Pharm Biopharm. 2015 Nov 28
  • Ye X, Patil H, Feng X, Tiwari RV, Lu J, Gryczke A, Kolter K, Langley N, Majumdar S, Neupane D, Mishra SR, Repka MA. Conjugation of Hot-Melt Extrusion with HighPressure Homogenization: a Novel Method of Continuously Preparing Nanocrystal Solid Dispersions. AAPS PharmSciTech. 2015 Aug 18