School of Pharmacy

The University of Mississippi

Dr. Philip Mosier

Posted on: July 2nd, 2018 by wltarpy
Assistant Professor of Medicinal Chemistry in BioMolecular Sciences and Research Assistant Professor in the Research Institute of Pharmaceutical Sciences
Faser 421
(662) 915-1071
 

Education:

  • Ph.D., Pennsylvania State University
  • B.S., Midland University

Appointment(s):

  • Assistant Professor of Medicinal Chemistry
  • Research Assistant Professor in the Research Institute of Pharmaceutical Sciences

Research:

Dr. Mosier specializes in the design, development and use of computational tools to understand the structure and function of proteins as well as their interactions with small-molecule and macromolecular modulators, with applications to molecular modeling, computational chemistry, structural biology, chem/bioinformatics and drug design.

Books/Book Chapters:

  • Designing “High-Affinity, High-Specificity” Glycosaminoglycan Sequences Through Computerized Modeling, Sankaranarayanan, N. V.; Sarkar, A.; Desai, U. R.; Mosier, P. D. In Methods Molecular Biology, Balagurunathan, K; Nakato, H.; Desai, U. R., Eds. Humana Press/Springer: New York, NY, 2015; Vol. 1229, pp 289–314.
  • Molecular Modeling: Considerations for the Design of Pharmaceuticals and Biopharmaceuticals, Mosier, P. D. and Kellogg, G. E. In Biopharmaceutical Drug Design and Development, 2nd ed.; Wu-Pong, S.; Rojanasakul, Y., Eds. Humana Press: Totowa, NJ, 2008; pp 267–291.

Recent Publications:

  • Che, T.; Majumdar, S.; Zaidi, S. A.; Ondachi, P.; McCorvy, J. D.; Wang, S.; Mosier, P. D.; Uprety, R.; Vardy, E.; Krumm, B. E.; Han, G. W.; Lee, M.-Y.; Pardon, E.; Steyaert, J.; Huang, X.-P.; Strachan, R. T.; Tribo, A. R.; Pasternak, G. W.; Carroll, F. I.; Stevens, R. C.; Cherezov, V.; Katritch, V.; Wacker, D.; Roth, B. L. Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor. Cell, 2018, 172, 55–67.
  • Chiang, M.-J.; Musayev, F. N.; Kosikova, M.; Lin, Z.; Gao, Y.; Mosier, P. D.; Althufairi, B.; Ye, Z.; Zhou, Q.; Desai, U. R.; Xie, H.; Safo, M. K. Maintaining pH-Dependent Conformational Flexibility of M1 Is Critical for Efficient Influenza A Virus Replication. Emerging Microbes Infect. 2017, 6, e108.
  • Sankaranarayanan, N. V.; Strebel, T. R.; Boothello, R. S.; Sheerin, K.; Raghuraman, A.; Sallas, F.; Mosier, P. D.; Watermeyer, N. D.; Oscarson, S.; Desai, U. R. A Hexasaccharide Containing Rare 2-O-Sulfate-Glucuronic Acid Residues Selectively Activates Heparin Cofactor II. Angew. Chem. Int. Ed. Engl. 2017, 56, 2312–2317.
  • Mosier, P. D.; Chiang, M.-J.; Lin, Z.; Gao, Y.; Althufairi, B.; Zhou, Q.; Musayev, F. N.; Safo, M. K.; Xie, H.; Desai, U. R. Broad Spectrum Anti-Influenza Agents by Inhibiting Self-Association of Matrix Protein 1. Sci. Rep. 2016, 6, 32340.
  • Alix, K.; Khatri, S.; Mosier, P. D.; Casterlow, S.; Yan, D.; Nyce, H. L.; White, M. M.; Schulte, M. K.; Dukat, M. Super-Agonist, Full Agonist, Partial Agonist and Antagonist Actions of Arylguanidines at h5-HT3A Receptors. ACS Chem. Neurosci. 2016, 7, 1565–1574.
  • Sarkar, A.; Yu, W.; Desai, U. R.; MacKerell, A. D., Jr.; Mosier, P. D. Estimating Glycosaminoglycan–Protein Interaction Affinity: Water Dominates the Specific Antithrombin–Heparin Interaction. Glycobiology 2016, 26, 1041–1047.
  • Joseph, P. R. B.; Mosier, P. D.; Desai, U. R.; Rajarathnam, K. Solution NMR Characterization of Chemokine CXCL8/IL-8 Monomer and Dimer Binding to Glycosaminoglycans: Structural Plasticity Mediates Differential Binding Interactions. Biochem. J. 2015, 472, 121–133.
  • Vardy, E.; Sassano, M. F.; Rennekamp, A. J.; Kroeze, W. K.; Mosier, P. D.; Westkaemper, R. B.; Stevens, C. W.; Katritch, V.; Stevens, R. C.; Peterson, R. T.; Roth, B. L. Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides. Chem. Biol. 2015, 22, 764–775.
  • Vardy, E.; Robinson, J. E.; Li, C.; Olsen, R. H. J.; DiBerto, J. F.; Giguere, P. M.; Sassano, M. F.; Huang, X.-P.; Zhu, H.; Urban, D. J.; White, K. L.; Rittiner, J. E.; Crowley, N. A.; Pleil, K. E.; Mazzone, C. M.; Mosier, P. D.; Song, J.; Kash, T. L.; Malanga, C. J.; Krashes, M. J.; Roth, B. L. A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. Neuron 2015, 86, 936–946. Featured on cover. Featured in Neuron Best of 2014/15.
  • Sakloth, F.; Kolanos, R.; Mosier, P. D.; Bonano, J. S.; Banks, M. L.; Partilla, J. S.; Baumann, M. H.; Negus, S. S.; Glennon, R. A. Steric Parameters, Molecular Modeling and Hydropathic Interaction Analysis of the Pharmacology of para-Substituted Methcathinone Analogues. Br. J. Pharmacol. 2015, 172, 2210–2218.
  • Yuan, Y.; Zaidi, S. A.; Stevens, D. L.; Scoggins, K. L.; Mosier, P. D.; Kellogg, G. E.; Dewey, W. L.; Selley, D. E.; Zhang, Y. Design, Syntheses, and Pharmacological Characterization of 17-Cyclopropylmethyl-3,14ß-dihydroxy-4,5a-epoxy-6a-(isoquinoline-3′-carboxamido)morphinan Analogues as Opioid Receptor Ligands. Bioorg. Med. Chem. 2015, 23, 1701–1715.
  • Safo, M.; Musayev, F. N.; Mosier, P. D.; Zhou, Q.; Xie, H.; Desai, U. R. Crystal Structures of Influenza a Virus Matrix Protein M1: Variations on a Theme. PLoS One 2014, 9, e109510.
  • Polepally, P. R.; Huben, K.; Setola, V.; Vardy, E.; Roth, B. L.; Mosier, P. D.; Zjawiony, J. K. Michael Acceptor Approach to the Design of New Salvinorin A-Based High Affinity Ligands for the Kappa-Opioid Receptor. Eur. J. Med. Chem. 2014, 85, 818–829.
  • Vardy, E.; Mosier, P. D.; Frankowski, K. J.; Wu, H.; Katritch, V.; Westkaemper, R. B.; Aubé, J.; Stevens, R. C.; Roth, B. L. Chemotype-Selective Modes of Action of ?-Opioid Receptor Agonists. J. Biol. Chem. 2013, 288, 34470–34483.
  • Zaidi, S. A.; Arnatt, C. K.; He, H.; Selley, D. E.; Mosier, P. D.; Kellogg, G. E.; Zhang, Y. Binding Mode Characterization of 6a- and 6ß-N-Heterocyclic Substituted Naltrexamine Derivatives via Docking in Opioid Receptor Crystal Structures and Site-Directed Mutagenesis Studies: Application of the “Message–Address” Concept in Development of Mu Opioid Receptor Selective Antagonists. Bioorg. Med. Chem. 2013, 21, 6405–6413.
  • Sidhu, P. S.; Mosier, P. D.; Zhou, Q.; Desai, U. R. On Scaffold Hopping: Challenges in the Discovery of Sulfated Small Molecules as Mimetics of Glycosaminoglycans. Bioorg. Med. Chem. Lett. 2013, 23, 355–359.
  • Xie, H.; Lin, Z.; Mosier, P. D.; Desai, U. R.; Gao, Y. The Compensatory G88R Change is Essential in Restoring the Normal Functions of Influenza A/WSN/33 Viral Matrix Protein 1 with Disrupted Nuclear Localization Signal. J. Virol. 2013, 87, 345–353.
  • Mosier, P. D.; Krishnasamy, C.; Kellogg, G. E.; Desai, U. R. On the Specificity of Heparin/Heparan Sulfate Binding to Proteins. Anion-Binding Sites on Antithrombin and Thrombin Are Fundamentally Different. PLoS One 2012, 7, e48632.
  • Abdel Aziz, M. H.; Sidhu, P. S.; Liang, A.; Kim, J. Y.; Mosier, P. D.; Zhou, P.; Farrell, D. H.; Desai, U. R. Designing Allosteric Regulators of Thrombin. Monosulfated Benzofuran Dimers Selectively Interact With Arg173 of Exosite II to Induce Inhibition. J. Med. Chem. 2012, 55, 6888–6897.
  • Wu, H.; Wacker, D.; Mileni, M.; Katritch, V.; Han, G. W.; Vardy, E.; Liu, W.; Thompson, A. A.; Huang, X.-P.; Carroll, F. I.; Mascarella, S. W.; Westkaemper, R. B.; Mosier, P. D.; Roth, B. L.; Cherezov, V.; Stevens, R. C. Structure of the Human ?-Opioid Receptor in Complex with JDTic. Nature 2012, 485, 327–332. Featured on cover.
  • Yuan, Y.; Mosier, P. D.; Zhang, Y. Quantitative Structure–Property Relationship (QSPR) Model for Predicting Acidities of Ketones. J. Biophys. Chem. 2012, 3, 49–57.

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