School of Pharmacy

The University of Mississippi

Dr. Philip Mosier

Posted on: July 2nd, 2018 by wltarpy
Assistant Professor of Medicinal Chemistry in BioMolecular Sciences and Research Assistant Professor in the Research Institute of Pharmaceutical Sciences
Faser 421
(662) 915-1071


  • Ph.D., Pennsylvania State University
  • B.S., Midland University


  • Assistant Professor of Medicinal Chemistry
  • Research Assistant Professor in the Research Institute of Pharmaceutical Sciences


Dr. Mosier specializes in the design, development and use of computational tools to understand the structure and function of proteins as well as their interactions with small-molecule and macromolecular modulators, with applications to molecular modeling, computational chemistry, structural biology, chem/bioinformatics and drug design.

Books/Book Chapters:

  • Designing “High-Affinity, High-Specificity” Glycosaminoglycan Sequences Through Computerized Modeling, Sankaranarayanan, N. V.; Sarkar, A.; Desai, U. R.; Mosier, P. D. In Methods Molecular Biology, Balagurunathan, K; Nakato, H.; Desai, U. R., Eds. Humana Press/Springer: New York, NY, 2015; Vol. 1229, pp 289–314.
  • Molecular Modeling: Considerations for the Design of Pharmaceuticals and Biopharmaceuticals, Mosier, P. D. and Kellogg, G. E. In Biopharmaceutical Drug Design and Development, 2nd ed.; Wu-Pong, S.; Rojanasakul, Y., Eds. Humana Press: Totowa, NJ, 2008; pp 267–291.

Recent Publications:

  • Che, T.; Majumdar, S.; Zaidi, S. A.; Ondachi, P.; McCorvy, J. D.; Wang, S.; Mosier, P. D.; Uprety, R.; Vardy, E.; Krumm, B. E.; Han, G. W.; Lee, M.-Y.; Pardon, E.; Steyaert, J.; Huang, X.-P.; Strachan, R. T.; Tribo, A. R.; Pasternak, G. W.; Carroll, F. I.; Stevens, R. C.; Cherezov, V.; Katritch, V.; Wacker, D.; Roth, B. L. Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor. Cell, 2018, 172, 55–67.
  • Chiang, M.-J.; Musayev, F. N.; Kosikova, M.; Lin, Z.; Gao, Y.; Mosier, P. D.; Althufairi, B.; Ye, Z.; Zhou, Q.; Desai, U. R.; Xie, H.; Safo, M. K. Maintaining pH-Dependent Conformational Flexibility of M1 Is Critical for Efficient Influenza A Virus Replication. Emerging Microbes Infect. 2017, 6, e108.
  • Sankaranarayanan, N. V.; Strebel, T. R.; Boothello, R. S.; Sheerin, K.; Raghuraman, A.; Sallas, F.; Mosier, P. D.; Watermeyer, N. D.; Oscarson, S.; Desai, U. R. A Hexasaccharide Containing Rare 2-O-Sulfate-Glucuronic Acid Residues Selectively Activates Heparin Cofactor II. Angew. Chem. Int. Ed. Engl. 2017, 56, 2312–2317.
  • Mosier, P. D.; Chiang, M.-J.; Lin, Z.; Gao, Y.; Althufairi, B.; Zhou, Q.; Musayev, F. N.; Safo, M. K.; Xie, H.; Desai, U. R. Broad Spectrum Anti-Influenza Agents by Inhibiting Self-Association of Matrix Protein 1. Sci. Rep. 2016, 6, 32340.
  • Alix, K.; Khatri, S.; Mosier, P. D.; Casterlow, S.; Yan, D.; Nyce, H. L.; White, M. M.; Schulte, M. K.; Dukat, M. Super-Agonist, Full Agonist, Partial Agonist and Antagonist Actions of Arylguanidines at h5-HT3A Receptors. ACS Chem. Neurosci. 2016, 7, 1565–1574.
  • Sarkar, A.; Yu, W.; Desai, U. R.; MacKerell, A. D., Jr.; Mosier, P. D. Estimating Glycosaminoglycan–Protein Interaction Affinity: Water Dominates the Specific Antithrombin–Heparin Interaction. Glycobiology 2016, 26, 1041–1047.
  • Joseph, P. R. B.; Mosier, P. D.; Desai, U. R.; Rajarathnam, K. Solution NMR Characterization of Chemokine CXCL8/IL-8 Monomer and Dimer Binding to Glycosaminoglycans: Structural Plasticity Mediates Differential Binding Interactions. Biochem. J. 2015, 472, 121–133.
  • Vardy, E.; Sassano, M. F.; Rennekamp, A. J.; Kroeze, W. K.; Mosier, P. D.; Westkaemper, R. B.; Stevens, C. W.; Katritch, V.; Stevens, R. C.; Peterson, R. T.; Roth, B. L. Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides. Chem. Biol. 2015, 22, 764–775.
  • Vardy, E.; Robinson, J. E.; Li, C.; Olsen, R. H. J.; DiBerto, J. F.; Giguere, P. M.; Sassano, M. F.; Huang, X.-P.; Zhu, H.; Urban, D. J.; White, K. L.; Rittiner, J. E.; Crowley, N. A.; Pleil, K. E.; Mazzone, C. M.; Mosier, P. D.; Song, J.; Kash, T. L.; Malanga, C. J.; Krashes, M. J.; Roth, B. L. A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. Neuron 2015, 86, 936–946. Featured on cover. Featured in Neuron Best of 2014/15.
  • Sakloth, F.; Kolanos, R.; Mosier, P. D.; Bonano, J. S.; Banks, M. L.; Partilla, J. S.; Baumann, M. H.; Negus, S. S.; Glennon, R. A. Steric Parameters, Molecular Modeling and Hydropathic Interaction Analysis of the Pharmacology of para-Substituted Methcathinone Analogues. Br. J. Pharmacol. 2015, 172, 2210–2218.
  • Yuan, Y.; Zaidi, S. A.; Stevens, D. L.; Scoggins, K. L.; Mosier, P. D.; Kellogg, G. E.; Dewey, W. L.; Selley, D. E.; Zhang, Y. Design, Syntheses, and Pharmacological Characterization of 17-Cyclopropylmethyl-3,14ß-dihydroxy-4,5a-epoxy-6a-(isoquinoline-3′-carboxamido)morphinan Analogues as Opioid Receptor Ligands. Bioorg. Med. Chem. 2015, 23, 1701–1715.
  • Safo, M.; Musayev, F. N.; Mosier, P. D.; Zhou, Q.; Xie, H.; Desai, U. R. Crystal Structures of Influenza a Virus Matrix Protein M1: Variations on a Theme. PLoS One 2014, 9, e109510.
  • Polepally, P. R.; Huben, K.; Setola, V.; Vardy, E.; Roth, B. L.; Mosier, P. D.; Zjawiony, J. K. Michael Acceptor Approach to the Design of New Salvinorin A-Based High Affinity Ligands for the Kappa-Opioid Receptor. Eur. J. Med. Chem. 2014, 85, 818–829.
  • Vardy, E.; Mosier, P. D.; Frankowski, K. J.; Wu, H.; Katritch, V.; Westkaemper, R. B.; Aubé, J.; Stevens, R. C.; Roth, B. L. Chemotype-Selective Modes of Action of ?-Opioid Receptor Agonists. J. Biol. Chem. 2013, 288, 34470–34483.
  • Zaidi, S. A.; Arnatt, C. K.; He, H.; Selley, D. E.; Mosier, P. D.; Kellogg, G. E.; Zhang, Y. Binding Mode Characterization of 6a- and 6ß-N-Heterocyclic Substituted Naltrexamine Derivatives via Docking in Opioid Receptor Crystal Structures and Site-Directed Mutagenesis Studies: Application of the “Message–Address” Concept in Development of Mu Opioid Receptor Selective Antagonists. Bioorg. Med. Chem. 2013, 21, 6405–6413.
  • Sidhu, P. S.; Mosier, P. D.; Zhou, Q.; Desai, U. R. On Scaffold Hopping: Challenges in the Discovery of Sulfated Small Molecules as Mimetics of Glycosaminoglycans. Bioorg. Med. Chem. Lett. 2013, 23, 355–359.
  • Xie, H.; Lin, Z.; Mosier, P. D.; Desai, U. R.; Gao, Y. The Compensatory G88R Change is Essential in Restoring the Normal Functions of Influenza A/WSN/33 Viral Matrix Protein 1 with Disrupted Nuclear Localization Signal. J. Virol. 2013, 87, 345–353.
  • Mosier, P. D.; Krishnasamy, C.; Kellogg, G. E.; Desai, U. R. On the Specificity of Heparin/Heparan Sulfate Binding to Proteins. Anion-Binding Sites on Antithrombin and Thrombin Are Fundamentally Different. PLoS One 2012, 7, e48632.
  • Abdel Aziz, M. H.; Sidhu, P. S.; Liang, A.; Kim, J. Y.; Mosier, P. D.; Zhou, P.; Farrell, D. H.; Desai, U. R. Designing Allosteric Regulators of Thrombin. Monosulfated Benzofuran Dimers Selectively Interact With Arg173 of Exosite II to Induce Inhibition. J. Med. Chem. 2012, 55, 6888–6897.
  • Wu, H.; Wacker, D.; Mileni, M.; Katritch, V.; Han, G. W.; Vardy, E.; Liu, W.; Thompson, A. A.; Huang, X.-P.; Carroll, F. I.; Mascarella, S. W.; Westkaemper, R. B.; Mosier, P. D.; Roth, B. L.; Cherezov, V.; Stevens, R. C. Structure of the Human ?-Opioid Receptor in Complex with JDTic. Nature 2012, 485, 327–332. Featured on cover.
  • Yuan, Y.; Mosier, P. D.; Zhang, Y. Quantitative Structure–Property Relationship (QSPR) Model for Predicting Acidities of Ketones. J. Biophys. Chem. 2012, 3, 49–57.

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